Han, Geonhee Cho, Haeun Kim, Hyosuk Jang, Yeongji Jang, Hochung Kim, Da Eun Kim, Eun Sun Kim, Eun Hye Hwang, Kwang Yeon Kim, Kwangmeyung Yang, Yoosoo Kim, Sun Hwa 2024-01-19T12:30:20Z 2024-01-19T12:30:20Z 2022-04-07 2022-04 2047-4830 https://pubs.kist.re.kr/handle/201004/115466 Despite the rise in the global burden of inflammatory bowel disease, there is a lack of safe and effective therapies that can meet the needs of clinical patients. In this study, we investigated the beneficial effects of bovine milk, especially colostrum-derived exosomes (Col-exo) in a murine model of ulcerative colitis induced by dextran sodium sulfate (DSS). Col-exo activated the proliferation of colonic epithelial cells and macrophages, and created an environment to relieve inflammation by effectively removing reactive oxygen species and regulating the expression of immune cytokines. Besides, Col-exo could pass through the gastrointestinal tract intact and efficiently deliver bioactive cargoes to the stomach, small intestine, and colon. Our results showed that oral gavage of Col-exo can alleviate colitis symptoms including weight loss, gastrointestinal bleeding, and chronic diarrhea by modulating intestinal inflammatory immune responses. Overall, bovine colostrum-derived exosomes with excellent structural and functional stability may offer great potential as natural therapeutics for the recovery of colitis. English Royal Society of Chemistry Bovine colostrum derived-exosomes prevent dextran sulfate sodium-induced intestinal colitis via suppression of inflammation and oxidative stress Article 10.1039/d1bm01797g 1 Biomaterials Science, v.10, no.8, pp.2076 - 2087 Biomaterials Science 10 8 2076 2087 N scie scopus 000771706900001 Materials Science, Biomaterials Materials Science Article DSS-INDUCED COLITIS BOWEL-DISEASE CELLS BIOLOGICS MICRORNAS ABUNDANT THERAPY IBD