Lee, Seul-Gi Kang, Ingu Seo, Mi-Na Lee, Jung-Eum Eom, Sang-Yong Hwang, Myung-Sil Park, Kyung Su Choi, Byung-Sun Kwon, Ho-Jang Hong, Young-Seoub Kim, Heon Park, Jung-Duck 2024-01-19T12:30:49Z 2024-01-19T12:30:49Z 2022-02-17 2022-04 0090-4341 https://pubs.kist.re.kr/handle/201004/115490 Arsenic is a human carcinogen. Data on urinary arsenic species analyses of Koreans are limited. This study evaluated the arsenic exposure level, contributing factors, and health effects in Korean adults. Dietary intake information and urine samples were obtained from 2044 participants. Arsenic exposure was assessed based on urinary concentrations of arsenic species, such as inorganic arsenic, As(III) and As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB), using high-performance liquid chromatography with inductively coupled plasma mass spectrometry, followed by determination of biomarkers, malondialdehyde and c-peptide. The geometric mean concentrations were 30.9 mu g/L for the sum of inorganic arsenic and their metabolites, and 84.7 mu g/L for the total sum of arsenic measured. Urinary concentrations of arsenic species were influenced by age, inhabitant area (inland or coastal), and seafood intake, which was positively correlated with inorganic arsenic, DMA, and AsB. Rice intake was positively correlated with inorganic arsenic and its metabolites but not with AsB. Additionally, malondialdehyde and c-peptide levels were significantly associated with urinary concentrations of various arsenic species. Seafood and rice are major sources of organic/inorganic arsenic exposure in Korean adults; however, it is necessary to evaluate whether their overconsumption could have a potentially detrimental effect on human health. English Springer Verlag Exposure Levels and Contributing Factors of Various Arsenic Species and Their Health Effects on Korean Adults Article 10.1007/s00244-022-00913-y 1 Archives of Environmental Contamination and Toxicology, v.82, no.3, pp.391 - 402 Archives of Environmental Contamination and Toxicology 82 3 391 402 N scie scopus 000752359500001 2-s2.0-85124307086 Environmental Sciences Toxicology Environmental Sciences & Ecology Toxicology Article; Early Access HPLC-ICP-MS DRINKING-WATER SPECIATION ANALYSIS URINARY-EXCRETION DIETARY EXPOSURE SEAFOOD INTAKE PUBLIC-HEALTH METABOLITES POPULATION BIOMARKERS Arsenic Species Analysis Health Effect