Park, G.W. Gong, Gyeong taek Joo, J.C. Song, J. Lee, J. Lee, J.-P. Kim, H.T. Ryu, M.H. Sirohi, R. Zhuang, X. Min, K. 2024-01-19T12:30:52Z 2024-01-19T12:30:52Z 2022-02-17 2022-04 1364-0321 https://pubs.kist.re.kr/handle/201004/115493 Due to concerns over climate change and the depletion of fossil fuels, recent studies have focused on biorefineries utilizing lignocellulosic biomass as a renewable feedstock for producing value-added fuels and chemicals. Among the components of lignocellulosic biomass, cellulosic/hemicellulosic components have mainly been utilized to obtain fermentable sugars in biorefineries, whereas lignin has commonly been treated as a byproduct thus far. Nonetheless, lignin is the most widely available macromolecule in nature; thus, recent biorefineries have paid special attention to lignin as an attractive source for renewable energy. Given that natural lignin is highly recalcitrant to breakdown, lignin degradation is the most significant issue for further valorization. Accordingly, biological approaches involving enzymes and microorganisms for lignin degradation are comprehensively reviewed in this study. Additionally, this review intensively addresses the recent progress in biotechnological lignin valorization including not only metabolic engineering for producing useful fuels and chemicals but also the use of lignin-based hybrid materials for biosensor and biomedical applications. Furthermore, future studies on challenging issues are suggested as an aid to developing feasible lignin-based biorefineries. The results discussed in this review might provide insights for zero-waste refineries utilizing all components of lignocellulosic biomass. ？ 2021 Elsevier Ltd English Elsevier Ltd Recent progress and challenges in biological degradation and biotechnological valorization of lignin as an emerging source of bioenergy: A state-of-the-art review Article 10.1016/j.rser.2021.112025 1 Renewable and Sustainable Energy Reviews, v.157 Renewable and Sustainable Energy Reviews 157 N scie scopus 000786655400001 2-s2.0-85121917145 Green & Sustainable Science & Technology Energy & Fuels Science & Technology - Other Topics Energy & Fuels Review DYE-DECOLORIZING PEROXIDASE SITE-DIRECTED MUTAGENESIS RHODOCOCCUS-JOSTII RHA1 WHITE-ROT FUNGUS KRAFT-LIGNIN ENZYMATIC-HYDROLYSIS VERSATILE PEROXIDASE SYNTHETIC LIGNIN ALKALI LIGNIN IRPEX-LACTEUS Lignin-based hybrid materials Ligninolytic enzyme Metabolic engineering for lignin valorization Microbial lignin degradation