Kim, Hyeon-Young Lee, Hyeon-Seong Kim, In-Hyeon Kim, Youngbae Ji, Moongi Oh, Songjin Kim, Doo-Young Lee, Wonjae Kim, Sung-Hwan Paik, Man-Jeong 2024-01-19T12:31:34Z 2024-01-19T12:31:34Z 2022-04-29 2022-03 1661-6596 https://pubs.kist.re.kr/handle/201004/115535 (1) Background: Progression of chronic obstructive pulmonary disease (COPD) leads to irreversible lung damage and inflammatory responses; however, biomarker discovery for monitoring of COPD progression remains challenging. (2) Methods: This study evaluated the metabolic mechanisms and potential biomarkers of COPD through the integrated analysis and receiver operating characteristic (ROC) analysis of metabolic changes in lung, plasma, and urine, and changes in morphological characteristics and pulmonary function in a model of PPE/LPS-induced COPD exacerbation. (3) Results: Metabolic changes in the lungs were evaluated as metabolic reprogramming to counteract the changes caused by the onset of COPD. In plasma, several combinations of phenylalanine, 3-methylhistidine, and polyunsaturated fatty acids have been proposed as potential biomarkers; the alpha-aminobutyric acid/histidine ratio has also been reported, which is a novel candidate biomarker for COPD. In urine, a combination of succinic acid, isocitric acid, and pyruvic acid has been proposed as a potential biomarker. (4) Conclusions: This study proposed potential biomarkers in plasma and urine that reflect altered lung metabolism in COPD, concurrently with the evaluation of the COPD exacerbation model induced by PPE plus LPS administration. Therefore, understanding these integrative mechanisms provides new insights into the diagnosis, treatment, and severity assessment of COPD. English Multidisciplinary Digital Publishing Institute (MDPI) Comprehensive Targeted Metabolomic Study in the Lung, Plasma, and Urine of PPE/LPS-Induced COPD Mice Model Article 10.3390/ijms23052748 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.5 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 5 Y scie scopus 000773683300001 2-s2.0-85125409444 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article OBSTRUCTIVE PULMONARY-DISEASE PERIPHERAL ARTERIAL-DISEASE FATTY-ACIDS EXACERBATIONS INFLAMMATION BIOMARKERS EXERCISE chronic obstructive pulmonary disease metabolomics PPE LPS-induced COPD exacerbation mice model receiver operating characteristic analysis potential biomarker