Jeon, Hyungju Hojin Lee Kwon, Dae-Hyuk Kim, Jiwon Keiko, Yamamoto Yook, Jang Soo FENG, LINQING Park, Hye Ran Lim, Yong Hoon Cho, Zang-Hee Paek, Sun Ha Kim, Jinhyun 2024-01-19T12:31:50Z 2024-01-19T12:31:50Z 2022-04-05 2022-03 2211-1247 https://pubs.kist.re.kr/handle/201004/115551 The subthalamic nucleus (STN) controls psychomotor activity and is an efficient therapeutic deep brain stimulation target in individuals with Parkinson's disease. Despite evidence indicating position-dependent therapeutic effects and distinct functions within the STN, the input circuit and cellular profile in the STN remain largely unclear. Using neuroanatomical techniques, we construct a comprehensive connectivity map of the indirect and hyperdirect pathways in the mouse STN. Our circuit-and cellular-level connectivities reveal a topographically graded organization with three types of indirect and hyperdirect pathways (external globus pallidus only, STN only, and collateral). We confirm consistent pathways into the human STN by 7 T MRIbased tractography. We identify two functional types of topographically distinct glutamatergic STN neurons (parvalbumin [PV+/-]) with synaptic connectivity from indirect and hyperdirect pathways. Glutamatergic PV+ STN neurons contribute to burst firing. These data suggest a complex interplay of information integration within the basal ganglia underlying coordinated movement control and therapeutic effects. English Cell Press Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus Article 10.1016/j.celrep.2022.110439 1 Cell Reports, v.38, no.9 Cell Reports 38 9 Y scie scopus 000764832100007 2-s2.0-85125234191 Cell Biology Cell Biology Article DEEP BRAIN-STIMULATION TRIPARTITE SUBDIVISION HYPOTHESIS GLUTAMATE-RECEPTOR SUBUNITS BASAL GANGLIA GLOBUS-PALLIDUS ENTOPEDUNCULAR NUCLEUS SYNAPTIC CONNECTIVITY PARKINSONS-DISEASE NEURONS RAT indirect and hyperdirect pathways subthalamic nucleus cell type connectivity firing pattern