Hyosuk Kim DAEUN KIM Han, Geonhee LIM NU RI KIM EUN HYE Yeongji Jang CHO HAEUN Jang Ho-chung Ki Hun Kim Sun Hwa Kim Yoosoo Yang 2024-01-19T12:32:39Z 2024-01-19T12:32:39Z 2022-02-17 2022-03 2192-2640 https://pubs.kist.re.kr/handle/201004/115593 As wound healing is an extremely complicated process, consisting of a cascade of interlocking biological events, successful wound healing requires a multifaceted approach to support appropriate and rapid transitions from the inflammatory to proliferative and remodeling phases. In this regard, here the potential use of bovine milk extracellular vesicles (EVs) to enhance wound healing is investigated. The results show that milk EVs promote fibroblast proliferation, migration, and endothelial tube formation. In particular, milk EVs derived from colostrum (Colos EVs) contain various anti-inflammatory factors facilitating the transition from inflammation to proliferation phase, as well as factors for tissue remodeling and angiogenesis. In an excisional wound mouse model, Colos EVs promote re-epithelialization, activate angiogenesis, and enhance extracellular matrix maturation. Interestingly, Colos EVs are further found to be quite resistant to freeze-drying procedures, maintaining their original characteristics and efficacy for wound repair after lyophilization. These findings on the superior stability and excellent activity of milk Colos EVs indicate that they hold great promise to be developed as anti-inflammatory therapeutics, especially for the treatment of cutaneous wounds. ？ 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH English John Wiley and Sons Ltd Harnessing the Natural Healing Power of Colostrum: Bovine Milk-Derived Extracellular Vesicles from Colostrum Facilitating the Transition from Inflammation to Tissue Regeneration for Accelerating Cutaneous Wound Healing Article 10.1002/adhm.202102027 1 Advanced healthcare materials, v.11, no.6 Advanced healthcare materials 11 6 Y scie scopus 000730655100001 2-s2.0-85121366894 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Article GROWTH-FACTORS DRUG-DELIVERY EXOSOMES CELLS DIFFERENTIATION PROLIFERATION ANGIOGENESIS PLASMINOGEN REGULATOR THERAPY angiogenesis anti-inflammation milk extracellular vesicles tissue remodeling wound healing