Koo, Sagang Park, Ok Kyu Kim, Jonghoon Han, Sang Ihn Yoo, Tae Yong Lee, Nohyun Kim, Young Geon Kim, Hyunjoong Lim, Chaehong Bae, Jong-Seong Jin, Yoo Kim, Dokyoon Choi, Seung Hong Hyeon, Taeghwan 2024-01-19T12:33:23Z 2024-01-19T12:33:23Z 2022-08-25 2022-02 1936-0851 https://pubs.kist.re.kr/handle/201004/115637 An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion of the Fenton reaction increases the risk of damaging normal cells along with the cancer cells. Therefore, a tailored strategy to selectively enhance the Fenton reactivity in tumors, for example, by taking advantage of the characteristics of the tumor microenvironment (TME), is in high demand. Herein, a heterogeneous CDT system based on copper-iron peroxide nanoparticles (CFp NPs) is designed for TME-mediated synergistic therapy. CFp NPs degrade under the mildly acidic conditions of TME, self-supply H2O2, and the released Cu and Fe ions, with their larger portions at lower oxidation states, cooperatively facilitate hydroxyl radical production through a highly efficient catalytic loop to achieve an excellent tumor therapeutic efficacy. This is distinct from previous heterogeneous CDT systems in that the synergism is closely coupled with the Cu+-assisted conversion of Fe3+ to Fe2+ rather than their independent actions. As a result, almost complete ablation of tumors at a minimal treatment dose is demonstrated without the aid of any other therapeutic modality. Furthermore, CFp NPs generate O-2 during the catalysis and exhibit a TME-responsive T-1 magnetic resonance imaging contrast enhancement, which are useful for alleviating hypoxia and in vivo monitoring of tumors, respectively. English American Chemical Society Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction Article 10.1021/acsnano.1c09171 1 ACS Nano, v.16, no.2, pp.2535 - 2545 ACS Nano 16 2 2535 2545 N scie scopus 000776691400071 2-s2.0-85124168731 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article METAL-ORGANIC FRAMEWORKS IRON-OXIDE NANOPARTICLES MAGNETIC NANOPARTICLES CANCER OXYGEN DEGRADATION CONTRAST HYPOXIA OXIDATION CATALYST antitumor agents cancer chemodynamic therapy Fenton reaction tumor microenvironment hypoxia