Yang, Sungwook Lee, Semin Park, Kitae Kim, Jinseok Cho, Jeiwon Shin, Hee-Sup Yoon, Eui-Sung 2024-01-19T12:39:35Z 2024-01-19T12:39:35Z 2022-03-07 2010 1050-4729 https://pubs.kist.re.kr/handle/201004/115769 A precise and implantable micromanipulator is presented for automatically advancing electrodes during single unit recordings in freely-behaving animals. The modular design and enhanced clamping mechanism with simple mechanical components are designed to provide reliable linear motion using a piezo motor with a stroke of 3 mm. To be specific, a closed loop control system, based on the position feedback from a magnetoresistive (MR) sensor, was implemented to overcome the non-linear characteristics of the piezo motor and to locate electrodes precisely at the targeted position with the accuracy of 1 mu m, even under load. The weight of the micromanipulator is only 0.84 g when it is fully assembled with the MR sensor, PCBs, and connectors. In addition, a protective cover is employed to prevent breakage during semi-chronic recording. The positioning performance of the micromanipulator was tested at various loading conditions using various control methods. Finally, the activities of a single unit were isolated successfully using small step adjustments, such as 1 to 5 mu m, in freely-moving mice. English IEEE Highly-Accurate, Implantable Micromanipulator for Single Neuron Recordings Conference 10.1109/ROBOT.2010.5509360 1 IEEE International Conference on Robotics and Automation (ICRA), pp.5070 - 5075 IEEE International Conference on Robotics and Automation (ICRA) 5070 5075 US Anchorage, AK 2010-05-03 2010 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA) 000284150001091 2-s2.0-77955814267 Proceedings Paper