Geonhee Han Hyosuk Kim Da Eun Kim Yeonjoo Ahn Joongsoo Kim Ye Ji Jang Kwangmeyung Kim Yoosoo Yang Sun Hwa Kim 2024-01-19T13:00:24Z 2024-01-19T13:00:24Z 2022-02-17 2022-02 1999-4923 https://pubs.kist.re.kr/handle/201004/115773 In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage. ？ 2022 by the authors. Licensee MDPI, Basel, Switzerland. English Multidisciplinary Digital Publishing Institute (MDPI) The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells Article 10.3390/pharmaceutics14020307 1 Pharmaceutics, v.14, no.2 Pharmaceutics 14 2 Y scie scopus 000765110000001 2-s2.0-85124095039 Pharmacology & Pharmacy Pharmacology & Pharmacy Article Bovine colostrum Exosome Fibroblast Keratinocyte Melanocyte Skin repair