Park, Sungwook Kim, Hojun Woo Kyoungmin Kim, Jeong-Min Jo, Hye-Jun Jeong, Youngdo Lee, Kwan Hyi 2024-01-19T13:01:31Z 2024-01-19T13:01:31Z 2022-04-03 2022-01 1530-6984 https://pubs.kist.re.kr/handle/201004/115841 SARS-CoV-2 variants are of particular interest because they can potentially increase the transmissibility and virulence of COVID-19 or reduce the effectiveness of available vaccines. However, screening SARS-CoV-2 variants is a challenge because biosensors target viral components that can mutate. One promising strategy is to screen variants via angiotensin-converting enzyme 2 (ACE2), a virus receptor shared by all known SARS-CoV-2 variants. Here we designed a highly sensitive and portable COVID-19 screening biosensor based on the virus receptor. We chose a dualgate field-effect transistor to overcome the low sensitivity of virusreceptor-based biosensors. To optimize the biosensor, we introduced a synthetic virus that mimics the important features of SARS-CoV-2 (size, bilayer structure, and composition). The developed biosensor successfully detected SARS-CoV-2 in 20 min and showed sensitivity comparable to that of molecular diagnostic tests (similar to 165 copies/ mL). Our results indicate that a virus-receptor-based biosensor can be an effective strategy for screening infectious diseases to prevent pandemics. English American Chemical Society SARS-CoV-2 Variant Screening Using a Virus-Receptor-Based Electrical Biosensor Article 10.1021/acs.nanolett.1c03108 1 Nano Letters, v.22, no.1, pp.50 - 57 Nano Letters 22 1 50 57 N scie scopus 000737851900001 2-s2.0-85122290424 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article; Early Access DIAGNOSIS SENSOR CORONAVIRUS COVID-19 SPIKE biosensor SARS-CoV-2 variant screening ACE2 virus receptor