Park, Chang-Beom Kim, Go-Eun On, Jiwon Pyo, Heesoo Park, June-Woo Cho, Sung-Hee 2024-01-19T13:01:32Z 2024-01-19T13:01:32Z 2022-04-03 2022-01 0147-6513 https://pubs.kist.re.kr/handle/201004/115842 This study investigates the adverse effects and the associated underlying mechanism of bisphenol S (BPS) exposure on reproductive endocrine activity in adult zebrafish. Fish were exposed for 21 days to different BPS concentrations (0, 8, 40, and 200 mu g/mL) determined via the lowest observed adverse effect level (LOAEL, i.e., < EC15 = 250 mu g/mL) for zebrafish embryos. Exposure to 200 mu g/mL BPS in female zebrafish in the absence of vitellogenic oocytes or the presence of degenerated oocytes in the ovary significantly decreased the biosynthesis of hepatic vitellogenin (VTG) mRNA, while hepatic VTG mRNA in male fish abundance was significantly elevated (P < 0.05). The levels of gonadal steroids were significantly increased in female zebrafish, while in male zebrafish, the levels of endogenous androgens were reduced (P < 0.05). However, the activities of 17 beta-estradiol and aromatase in male zebrafish were significantly elevated in all BPS exposure groups in male zebrafish (P < 0.05). Interestingly, thyroid hormone levels and residual whole-body BPS levels increased in female and male zebrafish with increasing exposure concentrations. A novel finding is that the response to BPS depends on zebrafish sex and tissue-specific responsiveness to the accumulation of BPS, suggesting that BPS may cause longterm environmental problems in adult zebrafish through tissue-specific suppression and hormonal imbalance. English Academic Press Sex-specific effects of bisphenol S with tissue-specific responsiveness in adult zebrafish: The antiandrogenic and antiestrogenic effects Article 10.1016/j.ecoenv.2021.113102 1 Ecotoxicology and Environmental Safety, v.229 Ecotoxicology and Environmental Safety 229 Y scie scopus 000740097500002 2-s2.0-85121459695 Environmental Sciences Toxicology Environmental Sciences & Ecology Toxicology Article REPRODUCTION SUBSTITUTE AROMATASE DANIO-RERIO ENDOCRINE DISRUPTION HORMONAL BALANCE EXPOSURE EXPRESSION AF 17-BETA-ESTRADIOL BPS Bioaccumulation Gonadal steroids Thyroids VTG mRNA