Heekyung Koh TaeYoung Park Yong An Chung Jong-Hwan Lee KIM HYUNG MIN 2024-01-19T13:02:26Z 2024-01-19T13:02:26Z 2022-01-10 2022-01 2168-2194 https://pubs.kist.re.kr/handle/201004/115896 Transcranial focused ultrasound (tFUS) is a promising non-invasive technique for treating neurological and psychiatric disorders. One of the challenges for tFUS is the disruption of wave propagation through the skull. Consequently, despite the risks associated with exposure to ionizing radiation, computed tomography (CT) is required to estimate the acoustic transmission through the skull. This study aims to generate synthetic CT (sCT) from T1-weighted magnetic resonance imaging (MRI) and investigate its applicability to tFUS acoustic simulation. We trained a 3D conditional generative adversarial network (3D-cGAN) with 15 subjects. We then assessed image quality with 15 test subjects: mean absolute error (MAE) = 85.72 +/- 9.50 HU (head) and 280.25 +/- 24.02 HU (skull), dice coefficient similarity (DSC) = 0.88 +/- 0.02 (skull). In terms of skull density ratio (SDR) and skull thickness (ST), no significant difference was found between sCT and real CT (rCT). When the acoustic simulation results of rCT and sCT were compared, the intracranial peak acoustic pressure ratio was found to be less than 4%, and the distance between focal points less than 1 mm. English Institute of Electrical and Electronics Engineers Inc. Acoustic Simulation for Transcranial Focused Ultrasound Using GAN-Based Synthetic CT Article 10.1109/JBHI.2021.3103387 1 IEEE Journal of Biomedical and Health Informatics, v.26, no.1, pp.161 - 171 IEEE Journal of Biomedical and Health Informatics 26 1 161 171 N scie scopus 000745829300020 2-s2.0-85123516253 Computer Science, Information Systems Computer Science, Interdisciplinary Applications Mathematical & Computational Biology Medical Informatics Computer Science Mathematical & Computational Biology Medical Informatics COMPUTED-TOMOGRAPHY PSEUDO-CT FEASIBILITY ATTENUATION NETWORK HEAD single-element transducer synthetic CT MRI only generative adversarial network conditional GAN transcranial focused ultrasound acoustic simulation