Chou, Namsun Shin, Hyogeun Kim, Kanghwan Chae, Uikyu Jang, Minsu Jeong, Ui-Jin Hwang, Kyeong-Seob Yi, Bumjun Lee, Seung Eun Woo, Jiwan Cho, Yakdol Lee, Changhyuk Baker, Bradley J. Oh, Soo-Jin Nam, Min-Ho Choi, Nakwon Cho, Il-Joo 2024-01-19T13:02:42Z 2024-01-19T13:02:42Z 2022-01-10 2022-01 2198-3844 https://pubs.kist.re.kr/handle/201004/115912 Cell-type-specific, activity-dependent electrophysiology can allow in-depth analysis of functional connectivity inside complex neural circuits composed of various cell types. To date, optics-based fluorescence recording devices enable monitoring cell-type-specific activities. However, the monitoring is typically limited to a single brain region, and the temporal resolution is significantly low. Herein, a multimodal multi-shank fluorescence neural probe that allows cell-type-specific electrophysiology from multiple deep-brain regions at a high spatiotemporal resolution is presented. A photodiode and an electrode-array pair are monolithically integrated on each tip of a minimal-form-factor silicon device. Both fluorescence and electrical signals are successfully measured simultaneously in GCaMP6f expressing mice, and the cell type from sorted neural spikes is identified. The probe's capability of combined electro-optical recordings for cell-type-specific electrophysiology at multiple brain regions within a neural circuit is demonstrated. The new experimental paradigm to enable the precise investigation of functional connectivity inside and across complex neural circuits composed of various cell types is expected. English Wiley-VCH Verlag A Multimodal Multi-Shank Fluorescence Neural Probe for Cell-Type-Specific Electrophysiology in Multiple Regions across a Neural Circuit Article 10.1002/advs.202103564 1 Advanced Science, v.9, no.2 Advanced Science 9 2 Y scie scopus 000720271300001 2-s2.0-85119293878 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article NEURONAL-ACTIVITY SILICON PROBES CALCIUM DYNAMICS INDICATORS POPULATIONS WIRELESS cell-type identification electrophysiology fluorescence signal genetically encoded indicator neural circuit neural probe