Muthusamy, Selvaraj Zhao, Long Rajalakshmi, Kanagaraj Zhu, Dongwei Wang, Shengjun Mack, John Lee, Kang-Bong Zhang, Long Zhu, Weihua 2024-01-19T13:02:56Z 2024-01-19T13:02:56Z 2021-10-21 2022-01 0039-9140 https://pubs.kist.re.kr/handle/201004/115925 This work describes (Z)-N-((Z)-2-(1,3,3-trimethylindolin-2ylidene)ethylidene)quinoline-8-amine (LYSO-QF), a high-performing and biocompatible dye comprised of quinoline and Fisher aldehyde moieties linked via an imine vinyl backbone with lysosome targeting ability that can be used to quantitatively detect the mercury ion (Hg2+) in biosystems and the natural environment. This is achieved by forming three different tetrameric, trimeric and dimeric complexes between Hg2+ and LYSO-QF with the limit of detection (LOD) of 11 nm. The complexes formed were analyzed with the aid of time-dependent density functional theory (TD-DFT) calculations. The concentration dependence of the Hg2+ complex fluorescence emission changes from grey-green to jade green and then to red as the different types of complex are formed. The favorable sensor properties of the LYSO-QF probe are demonstrated by monitoring different Hg2+ concentrations in buffer solutions, HeLa cells, zebrafish model samples and several different types of water sample. Experiments with Whatman paper strips demonstrate that the cost-effective LYSO-QF also has considerable potential for use in on-site Hg2+ detection with the naked eye. English Elsevier BV Quantitative Hg2+ detection via forming three coordination complexes using a lysosome targeting quinoline - Fisher aldehyde fluorophore Article 10.1016/j.talanta.2021.122884 1 Talanta, v.236 Talanta 236 N scie scopus 000697681300002 2-s2.0-85114936033 Chemistry, Analytical Chemistry Article INDUCTIVELY-COUPLED PLASMA FLUORESCENT SENSOR AQUEOUS-MEDIUM MASS-SPECTROMETRY MERCURY ION PROBE CHEMOSENSOR DYE Distinctive emission Fluorophore Mercury ion detection Fisher aldehyde Lysosome targeting