Yu, Subin Dohyub Jang Yuan, Hong Huang, Wen-Tse Kim, Minju Mota, Filipe Marques Liu, Ru-Shi Lee, Hyukjin Kim, Sehoon Kim, Dong Ha 2024-01-19T13:03:33Z 2024-01-19T13:03:33Z 2022-04-03 2021-12 1944-8244 https://pubs.kist.re.kr/handle/201004/115961 Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO(2)@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO(2)) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO(2) and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO(2), generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO(2) (77.3%) and UCNP@aTiO(2) (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO(2)@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agent, providing a valuable addition to light-triggered cancer treatments in deep tissue. English American Chemical Society Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy Article 10.1021/acsami.1c21949 1 ACS Applied Materials & Interfaces, v.13, no.49, pp.58422 - 58433 ACS Applied Materials & Interfaces 13 49 58422 58433 N scie scopus 000752977200017 2-s2.0-85120920013 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article GOLD NANORODS NANOPARTICLES WATER BIOCOMPATIBILITY PHOTOSENSITIZERS NANOCRYSTALS LUMINESCENCE MECHANISMS RESONANCE SURFACE upconversion localized surface plasmon resonance titanium dioxide photosensitizer phototherapy