Jegal, Jonghwan Kim, Tae-Young Park, No-June Jo, Beom-Geun Jo, Geon-A. Choi, Han-Seok Kim, Su-Nam Yang, Min Hye 2024-01-19T13:04:02Z 2024-01-19T13:04:02Z 2022-01-25 2021-12 2072-6643 https://pubs.kist.re.kr/handle/201004/115990 Plants of the genus Wikstroemia are traditionally used in China to treat various inflammatory diseases. The purpose of this study was to isolate the components of Wikstroemia ganpi (Siebold & Zucc.) Maxim., to evaluate their anti-atopic activities and to identify candidates with anti-atopic therapeutics. A total of 24 compounds were isolated by bioassay-guided separation, including one novel compound, which was tilianin 5-methyl ether. The anti-atopic activities of the isolated compounds were determined using TNF-alpha-treated RBL-2H3 cells and HaCaT cells. The mRNA expressions of IL-4, IL-6, GM-CSF, G-CSF and TRPV1 were reduced by luteolin 7-methyl ether. The study shows that the luteolin 7-methyl ether isolated from W. ganpi is a potential therapeutic agent for the treatment of atopic dermatitis. English MDPI ATOPIC-DERMATITIS PLANT FLAVONOIDS CONSTITUENTS COMPONENTS ANTIOXIDANTS PATHOGENESIS PINORESINOL COUMARINS INDICA STEMS Inhibitory Effects of Luteolin 7-Methyl Ether Isolated from Wikstroemia ganpi on Tnf-A/Ifn-Gamma Mixture-Induced Inflammation in Human Keratinocyte Article 10.3390/nu13124387 1 NUTRIENTS, v.13, no.12 NUTRIENTS 13 12 scie scopus 000736877300001 2-s2.0-85120701404 Nutrition & Dietetics Nutrition & Dietetics Article ATOPIC-DERMATITIS PLANT FLAVONOIDS CONSTITUENTS COMPONENTS ANTIOXIDANTS PATHOGENESIS PINORESINOL COUMARINS INDICA STEMS Wikstroemia ganpi atopic dermatitis tilianin 5-methyl ether luteolin 7-methyl ether interleukin 4