최동휘 노현희 임매순 지동우 2024-01-19T13:04:05Z 2024-01-19T13:04:05Z 2022-01-10 2021-12 1932-4545 https://pubs.kist.re.kr/handle/201004/115992 This paper presents a 288-pixel retinal prosthesis (RP) chip implemented in a 0.18 mu m CMOS process. The proposed light-to-stimulus duration converter (LSDC) and biphasic stimulator generate a wide range of retinal stimuli proportional to the incident light intensity at a low supply voltage of 1V. The implemented chip shows 25.5 dB dynamic stimulation range and the state-of-the art low power consumption of 4.49 nW/pixel. Ex-vivo experiments were performed with a mouse retina and patch-clamp recording. The electrical artifact recorded by the patch electrode demonstrates that the proposed chip can generate electrical stimuli that have different pulse durations depending on the light intensity. Correspondingly, the spike counts in a retinal ganglion cell (RGC) were successfully modulated by the brightness of the light stimuli. English Institute of Electrical and Electronics Engineers A 4.49nW/Pixel Light-to-Stimulus Duration Converter-Based Retinal Prosthesis Chip Article 10.1109/TBCAS.2021.3128418 1 IEEE Transactions on Biomedical Circuits and Systems, v.15, no.6, pp.1140 - 1148 IEEE Transactions on Biomedical Circuits and Systems 15 6 1140 1148 N scie scopus 000757856200007 2-s2.0-85124850712 Engineering, Biomedical Engineering, Electrical & Electronic Engineering Article PERCEPTUAL THRESHOLDS POWER STIMULATION ACTIVATION VOLTAGE Retina Photodiodes Low-power electronics Brightness Implants CMOS process Prosthetics CMOS sensor implantable chip local return light-to-stimulus duration converter low power retinal prostheses