Hee-Ju Lee Hyo-Moon Cho Eun-Jin Park Ba-Wool Lee Duc-Trong Nghiem Ha-Thanh-Tung Pham Cheol-Ho Pan Won-Keun Oh 2024-01-19T13:04:08Z 2024-01-19T13:04:08Z 2022-01-10 2021-12 0045-2068 https://pubs.kist.re.kr/handle/201004/115996 During an attempt to discover insulin mimetics, thirteen new triterpenoid saponins (1？13), including three phytolaccagenic acids (1, 2, and 12) and ten serjanic acids (3？11 and 13), as aglycones were isolated from a 70% ethanol extract of leaves and stems from Pericampylus glaucus. The chemical structures of compounds 1？13 were determined through spectroscopic data analysis, including NMR, IR, and HRESIMS. All isolated compounds (1？13) were evaluated using 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (2-NBDG) as a fluorescent-tagged glucose probe to determine their stimulatory effects on glucose uptake in differentiated 3 T3-L1 adipocyte cells. Consequently, four compounds (4, 7, 11, and 12) exhibited stimulatory effects on glucose uptake. ？ 2021 Elsevier Inc. English Academic Press Triterpenoid saponins from the leaves and stems of Pericampylus glaucus and their insulin mimetic activities Article 10.1016/j.bioorg.2021.105445 1 Bioorganic Chemistry, v.117 Bioorganic Chemistry 117 N scie scopus 000778189700008 2-s2.0-85117954511 Biochemistry & Molecular Biology Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article GLUCOSE-UPTAKE LAM. MERR. PERIGLAUCINE ACID Glucose uptake Insulin mimetic activities Menispermaceae Pericampylus glaucus Triterpenoid saponins