Choi, Kang-Min Kim, Jeong-Youn Kim, Yong-Wook Han, Jung-Won Im, Chang-Hwan Lee, Seung-Hwan 2024-01-19T13:31:08Z 2024-01-19T13:31:08Z 2022-04-05 2021-11 2045-2322 https://pubs.kist.re.kr/handle/201004/116157 Default mode network (DMN) is a set of functional brain structures coherently activated when individuals are in resting-state. In this study, we constructed multi-frequency band resting-state EEG-based DMN functional network models for major psychiatric disorders to easily compare their pathophysiological characteristics. Phase-locking values (PLVs) were evaluated to quantify functional connectivity; global and nodal clustering coefficients (CCs) were evaluated to quantify global and local connectivity patterns of DMN nodes, respectively. DMNs of patients with post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder, major depressive disorder (MDD), bipolar disorder, schizophrenia (SZ), mild cognitive impairment (MCI), and Alzheimer's disease (AD) were constructed relative to their demographically-matched healthy control groups. Overall DMN patterns were then visualized and compared with each other. In global CCs, SZ and AD showed hyper-clustering in the theta band; OCD, MCI, and AD showed hypo-clustering in the low-alpha band; OCD and MDD showed hypo-clustering and hyper-clustering in low-beta, and high-beta bands, respectively. In local CCs, disease-specific patterns were observed. In the PLVs, lowered theta-band functional connectivity between the left lingual gyrus and the left hippocampus was frequently observed. Our comprehensive comparisons suggest EEG-based DMN as a useful vehicle for understanding altered brain networks of major psychiatric disorders. English Nature Publishing Group Comparative analysis of default mode networks in major psychiatric disorders using resting-state EEG Article 10.1038/s41598-021-00975-3 1 Scientific Reports, v.11, no.1 Scientific Reports 11 1 Y scie scopus 000717008000021 2-s2.0-85118862636 Multidisciplinary Sciences Science & Technology - Other Topics Article OBSESSIVE-COMPULSIVE DISORDER FUNCTIONAL CONNECTIVITY ALZHEIMERS-DISEASE BRAIN MEMORY PTSD SCHIZOPHRENIA HETEROGENEITY METAANALYSIS ANATOMY