Lee, H. Kim, H.J. Chae, H. Yoon, N.E. Jung, B.H. 2024-01-19T13:31:38Z 2024-01-19T13:31:38Z 2022-01-10 2021-11 2223-7747 https://pubs.kist.re.kr/handle/201004/116189 Aster glehni F. Schmidt (AG), is a natural product known to have anti-obesity effects, but the mechanism underlying these effects is not well documented. We hypothesized that AG may have inhibitory effects on enzymes related to lipid accumulation. Herein, AG fractions were tested against HMG-CoA reductase (HMGR) and fatty acid synthase (FAS), two important enzymes involved in cholesterol and fatty acid synthesis, respectively. We found that dicaffeoylquinic acid (DCQA) methyl esters present in AG are largely responsible for the inhibition of HMGR and FAS. Since free DCQA is a major form present in AG, we demonstrated that a simple methylation of the AG extract could increase the overall inhibitory effects against those enzymes. Through this simple process, we were able to increase the inhibitory effect by 150%. We believe that our processed AG effectively modulates the HMGR and FAS activities, providing promising therapeutic potential for cholesterol-and lipid-lowering effects. ？ 2021 by the authors. Licensee MDPI, Basel, Switzerland. English MDPI AG Aster glehni f. Schmidt extract modulates the activities of hmg-coa reductase and fatty acid synthase Article 10.3390/plants10112287 1 Plants, v.10, no.11 Plants 10 11 N scie scopus 000725341400001 2-s2.0-85117620635 Plant Sciences Plant Sciences Article HEART-DISEASE INHIBITORS EXPRESSION CANCER DRUGS Aster glehni F. Schmidt Di-caffeoylquinic acid Fatty acid synthase HMG-CoA reductase LC？MS/MS Polyphenols