Jeong, K. Kim, D. Kim, H.J. Lee, Y.-D. Yoo, J. Jang, D. Lee, S. Park, H. Kim, Y. Singh, A. Ahn, D.J. Kim, D.H. Bang, J. Kim, J. Prasad, P.N. Kim, S. 2024-01-19T13:31:43Z 2024-01-19T13:31:43Z 2022-01-10 2021-11 1936-0851 https://pubs.kist.re.kr/handle/201004/116194 Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics. ？ 2021 American Chemical Society. English American Chemical Society Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics Article 10.1021/acsnano.1c07898 1 ACS Nano, v.15, no.11, pp.18394 - 18402 ACS Nano 15 11 18394 18402 N scie scopus 000747115200114 2-s2.0-85117294031 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article Ultrasonic imaging Echogenic Hybrid nanostructures Microbubbles Nanohybrids Near Infrared Near-infrared Structure-based Ultrasound imaging Ultrasound triggered drug deliveries Up-conversion Infrared devices Carbon dioxide Controlled drug delivery Gas generators Light Nanostructured materials Photons Plasmonics Targeted drug delivery Tumors microbubble nanohybrid near-infrared ultrasound upconversion