Kim, D. Lee, Y. Kim, H.-R. Park, Y.J. Hwang, H. Rhim, H. Kang, T. Choi, C.W. Lee, B. Kim, M.S. 2024-01-19T13:33:28Z 2024-01-19T13:33:28Z 2022-01-10 2021-10 2045-2322 https://pubs.kist.re.kr/handle/201004/116304 Sargassum serratifolium (C. Agardh) C.Agardh, a marine brown alga, has been consumed as a food and traditional medicine in Asia. A previous study showed that the meroterpenoid-rich fraction of an ethanolic extract of S. serratifolium (MES) induced adipose tissue browning and suppressed diet-induced obesity and metabolic syndrome？when orally supplemented. Sargahydroquinoic acid (SHQA) is a major component of MES. However, it is unclear whether SHQA regulates energy homeostasis through the central nervous system. To examine this, SHQA was administrated through the third ventricle in the hypothalamus in high-fat diet-fed C57BL/6 mice and investigated its effects on energy homeostasis. Chronic administration of SHQA into the brain reduced body weight without a change in food intake and improved metabolic syndrome-related phenotypes. Cold experiments and biochemical analyses indicated that SHQA elevated thermogenic signaling pathways, as evidenced by an increase in body temperature and UCP1 signaling in white and brown adipose tissues. Peripheral denervation experiments using 6-OHDA indicated that the SHQA-induced anti-obesity effect is mediated by the activation of the sympathetic nervous system, possibly by regulating genes associated with sympathetic outflow and GABA signaling pathways. In conclusion, hypothalamic injection of SHQA elevates peripheral thermogenic signaling and ameliorates diet-induced obesity. ？ 2021, The Author(s). English Nature Research Hypothalamic administration of sargahydroquinoic acid elevates peripheral thermogenic signaling and ameliorates high fat diet-induced obesity through the sympathetic nervous system Article 10.1038/s41598-021-00074-3 1 Scientific Reports, v.11, no.1 Scientific Reports 11 1 N scie scopus 000712891800005 2-s2.0-85118431696 Multidisciplinary Sciences Science & Technology - Other Topics Article ADIPOSE-TISSUE THERMOGENESIS SARGASSUM-SERRATIFOLIUM CHEMICAL SYMPATHECTOMY ETHANOLIC EXTRACT RICH FRACTION BRAIN Sargahydroquinoic acid Hypothalamus Thermogenesis obesity