Lee, D.-H. Choi, S. Park, Y. Jin, H.-S. 2024-01-19T13:33:31Z 2024-01-19T13:33:31Z 2022-01-10 2021-10 1424-8247 https://pubs.kist.re.kr/handle/201004/116307 The mucin (MUC) family is a group of highly glycosylated macromolecules that are abundantly expressed in mammalian epithelial cells. MUC proteins contribute to the formation of the mucus barrier and thus have protective functions against infection. Interestingly, some MUC proteins are aberrantly expressed in cancer cells and are involved in cancer development and progression, including cell growth, proliferation, the inhibition of apoptosis, chemoresistance, metabolic reprogramming, and immune evasion. With their unique biological and structural features, MUC proteins have been considered promising therapeutic targets and also biomarkers for human cancer. In this review, we discuss the biological roles of the transmembrane mucins MUC1 and MUC16 in the context of hallmarks of cancer and current efforts to develop MUC1-and MUC16-targeted therapies. ？ 2021 by the authors. Licensee MDPI, Basel, Switzerland. English MDPI Mucin1 and mucin16: Therapeutic targets for cancer therapy Article 10.3390/ph14101053 1 Pharmaceuticals, v.14, no.10 Pharmaceuticals 14 10 scie scopus 000716390800001 2-s2.0-85117912459 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Review EPITHELIAL OVARIAN-CANCER GROWTH-FACTOR RECEPTOR CELL LUNG-CANCER CARCINOMA-ASSOCIATED ANTIGEN MUC1 ONCOPROTEIN MONOCLONAL-ANTIBODY TUMOR-MARKER CA 125 IMMUNOLOGICAL RESPONSE MAINTENANCE THERAPY ADC (antibody-drug conjugate) Cancer vaccine CAR (chimeric antigen recep-tor) Immunotherapy MUC1 MUC16 Mucin