Selvaraj, Baskar Kim, Dae Woon Park, Jin-Soo Kwon, Hak Cheol Lee, Heesu Yoo, Ki-Yeon Lee, Jae Wook 2024-01-19T13:34:10Z 2024-01-19T13:34:10Z 2021-10-21 2021-10 0960-894X https://pubs.kist.re.kr/handle/201004/116349 The neuroprotective activity of 2-heptyl-3-hydroxy-4(1H)-quinolone (compound 1) was evaluated using the neurotoxicity of glutamate in the HT22 cell line. Compound 1, known as a signal molecule of the bacterial quorum-sensing system, protects neuronal cells from glutamate-induced neurotoxicity by inhibiting cellular Ca2+ uptake and glutamate-triggered ROS accumulation. MAPK signaling pathway inhibition by compound 1 was evaluated by immunoblotting the phosphorylation status of the proteins. Furthermore, pro-apoptotic protein levels and AIF translocation to the nucleus were found to be reduced by compound 1. In conclusion, compound 1 showed neuroprotective effects by inhibiting apoptotic neuronal cell death. English Pergamon Press Ltd. Neuroprotective effects of 2-heptyl-3-hydroxy-4-quinolone in HT22 mouse hippocampal neuronal cells Article 10.1016/j.bmcl.2021.128312 1 Bioorganic & Medicinal Chemistry Letters, v.49 Bioorganic & Medicinal Chemistry Letters 49 N scie scopus 000696625300002 2-s2.0-85112505334 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article OXIDATIVE STRESS GLUTAMATE ACTIVATION APOPTOSIS KINASE DEATH AIF MITOCHONDRIA INHIBITION TOXICITY Quinolone Glutamate Neuroprotective effects HT22 hippocampal neuronal cells MAPK