Um, seung hoon JAEHONG, LEE Song, I.-S. Ok, Myoung Ryul Kim, Yu Chan Han, Hyung Seop Rhee, S.-H. Jeon, Hojeong 2024-01-19T13:34:27Z 2024-01-19T13:34:27Z 2021-09-02 2021-10 2452-199X https://pubs.kist.re.kr/handle/201004/116368 Hydroxyapatite, an essential mineral in human bones composed mainly of calcium and phosphorus, is widely used to coat bone graft and implant surfaces for enhanced biocompatibility and bone formation. For a strong implant？bone bond, the bone-forming cells must not only adhere to the implant surface but also move to the surface requiring bone formation. However, strong adhesion tends to inhibit cell migration on the surface of hydroxyapatite. Herein, a cell migration highway pattern that can promote cell migration was prepared using a nanosecond laser on hydroxyapatite coating. The developed surface promoted bone-forming cell movement compared with the unpatterned hydroxyapatite surface, and the cell adhesion and movement speed could be controlled by adjusting the pattern width. Live-cell microscopy, cell tracking, and serum protein analysis revealed the fundamental principle of this phenomenon. These findings are applicable to hydroxyapatite-coated biomaterials and can be implemented easily by laser patterning without complicated processes. The cell migration highway can promote and control cell movement while maintaining the existing advantages of hydroxyapatite coatings. Furthermore, it can be applied to the surface treatment of not only implant materials directly bonded to bone but also various implanted biomaterials implanted that require cell movement control. ？ 2021 The Authors English Elsevier Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning Article 10.1016/j.bioactmat.2021.03.025 1 Bioactive Materials, v.6, no.10, pp.3608 - 3619 Bioactive Materials 6 10 3608 3619 Y scie scopus 000672673500046 2-s2.0-85103245248 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article OSTEOBLAST ADHESION METALLIC IMPLANTS MIGRATION SURFACE FIBRONECTIN VITRONECTIN COATINGS DIFFERENTIATION BEHAVIOR FILMS Cell migration control Cell tracking Hydroxyapatite patterning Laser engraving Nanosecond laser