Park, Kwideok Jung, Hyun Jung Son, Jim Sik Park, Ki Dong Kim, Jae-Jin Ahn, Kwang-Duk Han, Dong Kenn 2024-01-19T13:38:26Z 2024-01-19T13:38:26Z 2022-03-07 2007 1022-1360 https://pubs.kist.re.kr/handle/201004/116398 Biodegradable polymer scaffolds that have dual pores on the matrix were successfully prepared using a combination of gas foaming and phase separation methods. PLLA and PLGA were dissolved in dioxane/water at the ratios of 90/10, 87/13, or 85/15 (v/v), respectively. Sodium bicarbonate was then added to the polymer solution and freezed-dried, then subjected to a gas foaming process. Dual pore scaffolds have two distinct pore sizes: large pores in 200 similar to 300 mu m and small ones in 5 similar to 20 mu m, with the interconnected structure. Their porosities were ranged from 92 to 98%, significantly higher than those of unipore scaffold (90%). Two variables, water content (10, 13, and 15%) and freeze-drying temperature (FDT; -196, -70, and -20 degrees C), were introduced during the scaffold preparation. Mechanical compressive strength decreased as the polymer solution was gradually diluted with water (100/0 to 85/15, v/v). Earlier weight loss of the different scaffolds was found with FDT at -20 degrees C but the final result was the same, regardless of different FDTs used. These dual pore polymer scaffolds may thus be useful in tissue engineering applications. English WILEY-V C H VERLAG GMBH Preparation of biodegradable polymer scaffolds with dual pore system for tissue regeneration Conference 10.1002/masy.200750324 1 IUPAC International Symposium on Advanced Polymers for Emerging Technologies, v.249, pp.145 - 150 IUPAC International Symposium on Advanced Polymers for Emerging Technologies 249 145 150 GE Busan, SOUTH KOREA 2006-10-10 MACROMOLECULAR SYMPOSIA 000246451200025 2-s2.0-34547236596 Proceedings Paper