Park, Kwideok Jung, Hong Hee Son, Jun Sik Rhie, Jong-Won Park, Ki Dong Ahn, Kwang-Duk Han, Dong Keun 2024-01-19T13:38:38Z 2024-01-19T13:38:38Z 2022-03-07 2007 1013-9826 https://pubs.kist.re.kr/handle/201004/116411 Pluronic F127 has received increasing attention over many years as drug delivery systems, biomaterials, and hydrogels for tissue engineering. In this study, we synthesized temperature-sensitive and cell-adhesive triblock F127 copolymers, in which Arg-Gly-Asp (RGD) peptide ligand was grafted to Pluronic F127-4-methacryloxyethyl trimellitic anhydride (4-META) to obtain F127-META-RGD. The chemical structures of the F127-META-RGD block copolymers were confirmed by FTIR, H-1 and C-13 NMR, and GPC. The resultant F127-META-RGD showed very similar thermosensitive behaviors to F127 and 17127-META. The critical micelle temperature (CMT) of the F127 copolymers decreased in the order of F127 < F127-META < F127-META-RGD, whereas the particle size followed an opposite trend. Interactions between the F127 copolymers and adipose-clerived stein cells (ASC) were evaluated in terms of cell adhesion and proliferation on the hydrogel. These thermosensitive RGD-grafted Pluronic hydrogels that display the enhanced cell adhesiveness, are expected to be useful as a functional injectable scaffold for tissue engineering. English TRANS TECH PUBLICATIONS LTD Thermosensitive and cell-adhesive pluronic hydrogels for human adipose-derived stem cells Conference 10.4028/www.scientific.net/KEM.342-343.301 1 7th Asian Symposium on Biomedical Materials (ASBM7), v.342-343, pp.301 - + 7th Asian Symposium on Biomedical Materials (ASBM7) 342-343 301 + SZ Cheju Isl, SOUTH KOREA 2006-08-20 ASBM7: ADVANCED BIOMATERIALS VII 000246657900076 2-s2.0-34147155398 Proceedings Paper