Lee, Moon Kyu Lee, Changyang Kim, Dong Ryul Kwon, Ik Chan Choi, Kuiwon 2024-01-19T13:39:00Z 2024-01-19T13:39:00Z 2022-03-07 2007 1013-9826 https://pubs.kist.re.kr/handle/201004/116434 The purpose of the present study was to develop a polymer film loaded with drug to effectively prevent pin tract infection. It was found that the polymer, poly ethylene-co-vinyl acetate blended with tetrahydrofuran, showed better flexibility and deformability than the other polymers: poly caprolactone18 and poly caprolactone44. Polymer films, poly ethylene-co-vinyl acetate, were divided into five testing groups dependent on the loading concentration of rifampici (5, 10, 15, and 20 wt %). The surface morphology of polymer films was examined by a scanning electron microscopy. It was found that the concentration of drug was a main factor to determine the roughness of the film. Considering the roughness of polymer films, 5 wt %, of rifampicin might be the maximum concentration for further applications. Hence, the antibiotic drug-loaded polymer Films were manufactured by mixing poly(ethylene-co-vinylacetate) and tetrahydrofuran with rifampicin(antibiotic drug). The film cast was designed as a shape of disk (inner phi 5mm and outer phi\20mm) to be suitable for pins for external fixation in orhtopaedics. The drug-loaded polymer solvent. the amount of 0.6cc, was molded into the disk-shaped film and dried into a airtight box at 15 degrees C for 24 hrs. The drug release characteristics(1, 2, 3, 4 and 5 wt%) were examined as a function of soaking time in phosphate buffered saline (PBS, 10 ml) using an enzyme-linked immunosorbent assay. Rifampicin was linearly released for first 100 hrs(similar to 4 days) for all antibiotic drug-loaded Polymer films. Afterward, the drug was released at a slower pace as a function of square root of time until 1000 hrs (similar to 40 days). This slow drug release can be explained by their hydrophobic characteristics of poly ethylene-co-vinyl acetate and rifampicin. The antibiotic drug-loaded polymer film can be intrinsically able to prevent the bacteria adhesion by wrapping the pin track area, and perform active and effective infection-resistant by a sustained antibiotic-release. English TRANS TECH PUBLICATIONS LTD The study of antibiotic drug-loaded polymer films for the prevention of the infection of external fixation devices Conference 10.4028/www.scientific.net/KEM.342-343.533 1 7th Asian Symposium on Biomedical Materials (ASBM7), v.342-343, pp.533 - + 7th Asian Symposium on Biomedical Materials (ASBM7) 342-343 533 + SZ Cheju Isl, SOUTH KOREA 2006-08-20 ASBM7: ADVANCED BIOMATERIALS VII 000246657900134 2-s2.0-34147156337 Proceedings Paper