Kim, Sungwon Nam, Yun Sik Min, Yeon Jin Kim, Jong-Ho Kim, Kwangmeyong Choi, Kui Won Noh, Insup Kwon, Ick Chan 2024-01-19T13:39:05Z 2024-01-19T13:39:05Z 2022-03-07 2007 1013-9826 https://pubs.kist.re.kr/handle/201004/116440 Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery, have been extensively investigated because of their great influence on the drug release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophore-labeled bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of the coated layer induced the core material instable, The results indicated that while the charges of the shell material provided additional diffusion barrier against the protein release, the key factor to hold the proteins inside the microspheres was the integrity of the outer coating layer. English TRANS TECH PUBLICATIONS LTD Release profile of a model protein drug depending on the stability of microspheres based on polyelectrolyte complex Conference 10.4028/www.scientific.net/KEM.342-343.505 1 7th Asian Symposium on Biomedical Materials (ASBM7), v.342-343, pp.505 - + 7th Asian Symposium on Biomedical Materials (ASBM7) 342-343 505 + SZ Cheju Isl, SOUTH KOREA 2006-08-20 ASBM7: ADVANCED BIOMATERIALS VII 000246657900127 2-s2.0-34147105069 Proceedings Paper