Okamoto, Masahiro Mizuuchi, Daisuke Omura, Koki Lee, Minchul Oharazawa, Akihiko Yook, Jang Soo Inoue, Koshiro Soya, Hideaki 2024-01-19T14:00:43Z 2024-01-19T14:00:43Z 2022-04-03 2021-09 1047-3211 https://pubs.kist.re.kr/handle/201004/116485 High-intensity intermittent (or interval) training (HIIT) has started to gain popularity as a time-effective approach to providing beneficial effects to the brain and to peripheral organs. However, it still remains uncertain whether HIIT enhances hippocampal functions in terms of neurogenesis and spatial memory due to unconsidered HIIT protocol for rodents. Here, we established the HIIT regimen for rats with reference to human study. Adult male Wistar rats were assigned randomly to Control, moderate-intensity continuous training (MICT; 20 m/min, 30 min/day, 5 times/week), and HIIT (60 m/min, 10 30-s bouts of exercise, interspaced with 2.5 min of recovery, 5 times/week) groups. The ratios of exercise time and volume between MICT and HIIT were set as 6:1 and 2:1-4:1, respectively. After 4 weeks of training, all-out time in the incremental exercise test was prolonged for exercise training. In skeletal muscle, the plantaris citrate synthase activity significantly increased only in the HIIT group. Simultaneously, both HIIT and MICT led to enhanced spatial memory and adult hippocampal neurogenesis (AHN) as well as enhanced protein levels of hippocampal brain-derived neurotrophic factor (BDNF) signaling. Collectively, we suggest that HIIT could be a time-efficient exercise protocol that enhances hippocampal memory and neurogenesis in rats and is associated with hippocampal BDNF signaling. English Oxford University Press High-intensity Intermittent Training Enhances Spatial Memory and Hippocampal Neurogenesis Associated with BDNF Signaling in Rats Article 10.1093/cercor/bhab093 1 Cerebral Cortex, v.31, no.9, pp.4386 - 4397 Cerebral Cortex 31 9 4386 4397 N scie scopus 000741349100030 2-s2.0-85113611731 Neurosciences Neurosciences & Neurology Article NEUROTROPHIC FACTOR BDNF HUMAN SKELETAL-MUSCLE INTERVAL EXERCISE EXECUTIVE FUNCTION MITOCHONDRIAL BIOGENESIS FUNCTIONAL HYPEREMIA MODERATE EXERCISE PHYSICAL-EXERCISE AEROBIC FITNESS SPRINT INTERVAL adult hippocampal neurogenesis high-intensity intermittent training spatial memory