Lee, Hee-Ju Park, Eun-Jin Lee, Ba-Wool Cho, Hyo-Moon Thi-Linh-Giang Pham Quynh-Hoa Hoang Pan, Cheol-Ho Oh, Won-Keun 2024-01-19T14:01:09Z 2024-01-19T14:01:09Z 2022-01-10 2021-09 1424-8247 https://pubs.kist.re.kr/handle/201004/116512 The accumulation of amyloid beta (A beta) peptides is common in the brains of patients with Alzheimer's disease, who are characterized by neurological cognitive impairment. In the search for materials with inhibitory activity against the accumulation of the A beta peptide, seven undescribed flavanonol glycosides (1-7) and five known compounds (8-12) were isolated from stems of Myrsine seguinii by HPLC-qTOF MS/MS-based molecular networking. Interestingly, this plant has been used as a folk medicine for the treatment of various inflammatory conditions. The chemical structures of the isolated compounds (1-12) were elucidated based on spectroscopic data, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS) and electronic circular dichroism (ECD) data. Compounds 2, 6 and 7 showed neuroprotective activity against A beta-induced cytotoxicity in A beta(42)-transfected HT22 cells. English MDPI ALZHEIMERS-DISEASE OXIDATIVE STRESS ACID-B LEAVES ROXBURGHIANA GALANTAMINE Flavanonol Glycosides from the Stems of Myrsine seguinii and Their Neuroprotective Activities Article 10.3390/ph14090911 1 PHARMACEUTICALS, v.14, no.9 PHARMACEUTICALS 14 9 scie scopus 000701949700001 2-s2.0-85114993153 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article ALZHEIMERS-DISEASE OXIDATIVE STRESS ACID-B LEAVES ROXBURGHIANA GALANTAMINE Myrsine seguinii Primulaceae Alzheimer&apos s disease flavanonol glycoside molecular networking neuroprotective activity