Kim, Hyosuk Jang, Hochung Cho, Haeun Choi, Jiwon Hwang, Kwang Yeon Choi, Yeonho Kim, Sun Hwa Yang, Yoosoo 2024-01-19T14:01:14Z 2024-01-19T14:01:14Z 2022-01-10 2021-09 2072-6694 https://pubs.kist.re.kr/handle/201004/116518 Simple Summary Exosomes derived from various sources can deliver therapeutic agents such as small molecule drugs, nucleic acids, and proteins to cancer cells by passive or active targeting. These exosomes can encapsulate drugs inside the exosomes, extending drug half-life and increasing drug release stability. In addition, exosomes are highly biocompatible due to their endogenous origin and can be used as nanocarriers for tissue-specific targeted delivery. This review discusses recent advances in exosome-based drug delivery for cancer therapy. Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes. English MDPI CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS SMALL-INTERFERING RNA NEONATAL FC-RECEPTOR INHIBIT IN-VITRO EXTRACELLULAR VESICLES DENDRITIC CELLS MILK EXOSOMES SIRNA DELIVERY NANO-CARRIERS Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy Article 10.3390/cancers13174435 1 CANCERS, v.13, no.17 CANCERS 13 17 scie scopus 000694208800001 2-s2.0-85114111356 Oncology Oncology Review CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS SMALL-INTERFERING RNA NEONATAL FC-RECEPTOR INHIBIT IN-VITRO EXTRACELLULAR VESICLES DENDRITIC CELLS MILK EXOSOMES SIRNA DELIVERY NANO-CARRIERS exosome drug delivery system cancer therapy exosome engineering