Jang, Hochung Kim, Eun Hye Chi, Sung-Gil Kim, Sun Hwa Yang, Yoosoo 2024-01-19T14:01:21Z 2024-01-19T14:01:21Z 2022-01-10 2021-09 1661-6596 https://pubs.kist.re.kr/handle/201004/116526 A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments. English MDPI IRON-OXIDE NANOPARTICLES MYELOID SUPPRESSOR-CELLS DRUG-DELIVERY SYSTEMS DENDRITIC CELLS MACROPHAGE POLARIZATION SILVER NANOPARTICLES RECENT PROGRESS IN-VITRO CANCER ANTIGEN Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment Article 10.3390/ijms221810009 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.18 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 18 scie scopus 000700717500001 2-s2.0-85114995029 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review IRON-OXIDE NANOPARTICLES MYELOID SUPPRESSOR-CELLS DRUG-DELIVERY SYSTEMS DENDRITIC CELLS MACROPHAGE POLARIZATION SILVER NANOPARTICLES RECENT PROGRESS IN-VITRO CANCER ANTIGEN nanoparticles innate immune cells tumor microenvironment cancer therapy