Kwon, Jaeyoung Hwang, Hoseong Selvaraj, Baskar Lee, Jung Hwan Park, Woongbi Ryu, Seung Mok Lee, Dongho Park, Jin-Soo Kim, Hyoung Seok Lee, Jae Wook Jang, Dae Sik Kwon, Hak Cheol 2024-01-19T14:01:32Z 2024-01-19T14:01:32Z 2021-10-21 2021-09 0045-2068 https://pubs.kist.re.kr/handle/201004/116537 The consumption of sprouts has been steadily increasing due to their being an excellent source of nutrition. It is known that the bioactive constituents of legumes can be increased after germination. In this study, the extract from Senna tora sprouts is shown to exhibit improved radical scavenging activities and better neuroprotective effects in HT22 hippocampal neuronal (HT22) and R28 retina precursor (R28) cells than those from seeds due to an increased content of phenolic constituents, especially compounds 1 and 3-6. A phytochemical investigation of S. tora sprouts resulted in the isolation of two new naphthopyrone glycosides (1-2) with 27 previously reported compounds. Their structures were determined via interpreting spectroscopic data. Compounds 1 and 3-6 were found to possess radical scavenging activities and neuroprotective effects against oxidative stress in both neuronal cells. Hence, Senna tora sprouts and their constituents may be developed as natural neuroprotective agents via antioxidative effects. English Academic Press Phenolic constituents isolated from Senna tora sprouts and their neuroprotective effects against glutamate-induced oxidative stress in HT22 and R28 cells Article 10.1016/j.bioorg.2021.105112 1 Bioorganic Chemistry, v.114 Bioorganic Chemistry 114 N scie scopus 000689722300003 2-s2.0-85114959028 Biochemistry & Molecular Biology Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article PURGATIVE CRUDE DRUGS CASSIA-TORA INHIBITORY-ACTIVITY SEEDS ANTIOXIDANT OBTUSIFOLIA GLUCOSIDES PROTEIN ANTHRAQUINONES DERIVATIVES Sprout Senna tora Fabaceae Naphthopyrone Antioxidant Neuroprotective effect