Ryu, S.M. Nguyen, Q.N. Lee, S. Kwon, H. Kwon, J. Lee, H. Kwon, S.L. Lee, J. Hwang, B.Y. Yim, J.-H. Guo, Y. Kim, J.-J. Kang, K.S. Lee, D. 2024-01-19T14:01:56Z 2024-01-19T14:01:56Z 2021-09-02 2021-09 0045-2068 https://pubs.kist.re.kr/handle/201004/116564 Eight new naphtho[1,2-c]furan derivatives (1？8) along with six known analogues (9？14) were isolated from culture medium of the basidiomycete Basidioradulum radula. The structures of these compounds were identified using spectroscopic analysis, and their absolute configurations were resolved using X-ray diffraction, ECD, and VCD. Compounds 7 and 14 inhibited the cell viability of human prostate cancer DU-145 cells with IC50 values of 7.54 ± 0.03 μM and 5.04 ± 0.03 μM, respectively. At 8 μM, compounds 7 and 14 increased the percentage of apoptotic cells and upregulated the protein expression related to the apoptosis caspase pathways in DU-145 cells. Furthermore, the hallmarks of cells undergoing apoptosis, such as chromatin condensation, were also observed at this concentration. However, compound 7 and 14 showed no effect on the proliferation of splenocytes isolated from cyclophosphamide-induce immunosuppressed mice. ？ 2021 Elsevier Inc. English Academic Press Inc. Chemical constituents from basidiomycete Basidioradulum radula culture medium and their cytotoxic effect on human prostate cancer DU-145 cells Article 10.1016/j.bioorg.2021.105064 1 Bioorganic Chemistry, v.114 Bioorganic Chemistry 114 N scie scopus 000689508200003 2-s2.0-85107801856 Biochemistry & Molecular Biology Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article CYTOCHROME-C RELEASE INVASION APOPTOSIS MIGRATION ACTIVATION MECHANISMS PATHWAYS RECEPTOR GROWTH DEATH Basidiomycete Basidioradulum radula Cytotoxicity DU-145 prostate cancer cell Hyphodermin