Kim, Seong A. Nam, Gi-hoon Bae, Young Rang Jha, Saurav Kumar Kim, Seohyun Choi, Yoonjeong Lee, Yeji Kwon, Minsu Jeong, Cheolhyun Byun, Youngro Park, Jin Woo Kim, In-San 2024-01-19T14:02:45Z 2024-01-19T14:02:45Z 2022-01-25 2021-08 2366-3987 https://pubs.kist.re.kr/handle/201004/116616 Statins exhibit anticancer pleiotropic effects, such as the induction tumor-specific apoptosis and the promotion antitumor immunity. However, due to low bioavailability, high doses are required to trigger such antitumor effects. In this study, an oral delivery system to improve bioavailability of simvastatin (SIMVA) is prepared and its application in combination with an oral anticancer formulation is investigated. A colloidal dispersion (CD) of SIMVA is prepared using Nα-deoxycholyl-l-lysyl-methylester (DL) to enhance a solubility and permeation (SIMVA/DL-CD). Preparation of SIMVA/DL-CD markedly increases the solubility and in vitro artificial membrane permeability of SIMVA by 291- and 4.68-fold, respectively, compared to SIMVA in 5% dimethyl sulfoxide. The oral absorption of SIMVA/DL-CD (20 mg kg−1 SIMVA) is significantly enhanced and its oral bioavailability is tenfold higher compared to that of free SIMVA. An in vivo study in CT26 tumor-bearing mice receiving SIMVA/DL-CD reveals substantial tumor growth suppression through upregulated anticancer immunity. In particular, the combination of oral SIMVA/DL-CD and oxaliplatin powder formulation elicits considerable tumor-suppressive effects and CD8+ T cell immunity. Furthermore, this combination therapy sensitizes antiprogramed cell death protein-1 monoclonal antibody-resistant tumors to checkpoint blockade. The current findings highlight the therapeutic potential of oral SIMVA/DL-CD as an effective anticancer immunotherapy. English Wiley Blackwell Oral Cancer Immunotherapy through a Simvastatin-Loaded Colloidal Dispersion System for the Generation of Sustained Antitumor Immunity Article 10.1002/adtp.202100025 1 Advanced Therapeutics, v.4, no.8 Advanced Therapeutics 4 8 N scie scopus 000632816000001 2-s2.0-85107091813 Pharmacology & Pharmacy Pharmacology & Pharmacy Article oxaliplatin simvastatin immunotherapy oral delivery colloidal dispersion