Lee, Yeontaek Shin, Hyogeun Lee, Dongwon Choi, Sungah Cho, Il-Joo Seo, Jungmok 2024-01-19T14:02:59Z 2024-01-19T14:02:59Z 2021-10-21 2021-08 2198-3844 https://pubs.kist.re.kr/handle/201004/116631 Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune-stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs. English WILEY BRAIN-TISSUE ASTROGLIOSIS ELECTRODES RESPONSES SURFACES POLYMER IMPACT NEEDLE ARRAY A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording Article 10.1002/advs.202100231 1 ADVANCED SCIENCE, v.8, no.15 ADVANCED SCIENCE 8 15 scie scopus 000657519900001 2-s2.0-85107116454 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article BRAIN-TISSUE ASTROGLIOSIS ELECTRODES RESPONSES SURFACES POLYMER IMPACT NEEDLE ARRAY bio inspired surface brain-machine interfaces neural probe nonimmunogenic properties