Lee, Gakyung Park, Young Suk Cho, Chamlee Lee, Hyunbeom Park, Jinyoung Park, Do Joong Lee, Joo Ho Lee, Hyuk-Joon Ha, Tae Kyung Kim, Yong-Jin Ryu, Seung-Wan Han, Sang-Moon Yoo, Moon-Won Park, Sungsoo Han, Sang-Uk Heo, Yoonseok Jung, Byung Hwa 2024-01-19T14:03:24Z 2024-01-19T14:03:24Z 2021-10-21 2021-08 1573-3882 https://pubs.kist.re.kr/handle/201004/116659 Introduction Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes in metabolism throughout the whole body. However, short-term metabolism studies associated with bariatric surgery in Asian individuals have not been reported. Objectives The aim of this study was to investigate the short-term metabolome changes in the serum promoted by laparoscopic sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) and to determine the underlying mechanisms that affect obesity-related comorbidities. Methods Serum samples were collected from Korean patients who underwent RYGB or SG before and 4 weeks after the surgery. Metabolomic and lipidomic profiling was performed using UPLC-Orbitrap-MS, and data were analyzed using statistical analysis. Results Metabolites mainly related to amino acids, lipids (fatty acids, glycerophospholipids, sphingolipids, glycerolipids) and bile acids changed after surgery, and these changes were associated with the lowering of risk factors for obesity-related diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and atherosclerosis. Interestingly, the number of significantly altered metabolites related to the lipid metabolism were greater in SG than in RYGB. Furthermore, the metabolites related to amino acid metabolism were significantly changed only after SG, whereas bile acid changed significantly only following RYGB. Conclusion These differences could result from anatomical differences between the two surgeries and could be related to the gut microbiota. This study provides crucial information to expand the knowledge of the common but different molecular mechanisms involved in obesity and obesity-related comorbidities affected by each bariatric procedure. English SPRINGER BARIATRIC SURGERY GUT MICROBIOTA OBESITY WEIGHT RISK Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass Article 10.1007/s11306-021-01826-y 1 METABOLOMICS, v.17, no.8 METABOLOMICS 17 8 scie scopus 000681742800001 2-s2.0-85112020889 Endocrinology & Metabolism Endocrinology & Metabolism Article BARIATRIC SURGERY GUT MICROBIOTA OBESITY WEIGHT RISK Bariatric surgery Laparoscopic sleeve gastrectomy Roux-en-Y gastric bypass Metabolomics Lipidomics