Lim, H. JIN, SOYEONG Jeong, Young do Kim, S.-B. Jang, D.-J. Kim, S.T. 2024-01-19T14:03:33Z 2024-01-19T14:03:33Z 2021-09-02 2021-08 1226-086X https://pubs.kist.re.kr/handle/201004/116669 The aim of this study was to investigate the effect of hydroxypropyl-β-cyclodextrin (HPβCD), widely used as a solubility enhancer, on liposomal formulations. To this end, HPβCD was added to fabricate liposomes during the hydration process, and their physicochemical properties were evaluated. The Fourier transform infrared and nuclear magnetic resonance spectra revealed that HPβCD could interact with the model drug, ceftazidime (CAZ), and with phosphatidylcholine, a main component of liposomes. This leads to a rapid release of CAZ depending on the concentration of HPβCD. Nanosized HPβCD-incorporated liposomes complied with Korsmeyer？Peppas kinetics, and the release of drug increased without significant changes in the release pattern. Our approach, which relied on supramolecule-related interactions, could provide new insights into other lipid-based formulations for accelerating drug-release properties. ？ 2021 The Korean Society of Industrial and Engineering Chemistry English 한국공업화학회 Preparation of hydroxypropyl-β-cyclodextrin-incorporated liposomes and evaluation of their rapid release property Article 10.1016/j.jiec.2021.05.002 1 Journal of Industrial and Engineering Chemistry, v.100, pp.59 - 62 Journal of Industrial and Engineering Chemistry 100 59 62 N scie scopus kci 000671222300004 2-s2.0-85106317279 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article Cyclodextrins Drug interactions Liposomes Magnetic resonance spectroscopy Physicochemical properties Targeted drug delivery Beta-cyclodextrin Drug release properties Fourier transform infra reds Hydration process Liposomal formulation Phosphatidylcholine Release pattern Supramolecules Controlled drug delivery Ceftazidime Hydroxypropyl-β-cyclodextrin Liposome Rapid release