Park, Jae Sung Ko, Keebeom Kim, Seong-Hwan Lee, Jae Kyun Park, Jin-Soo Park, Keunwan Kim, Mi Ri Kang, Kyungsu Oh, Dong-Chan Kim, Sun Yeou Yumnam, Silvia Kwon, Hak Cheol Shin, Jongheon 2024-01-19T14:03:44Z 2024-01-19T14:03:44Z 2021-10-21 2021-07-23 0163-3864 https://pubs.kist.re.kr/handle/201004/116680 The tropolone-bearing sesquiterpenes juniperone A (1) and norjuniperone A (2) were isolated from the folk medicinal plant Juniperus chinensis, and their structures were determined by a combination of spectroscopic and crystallographic methods. Photojuniperones A1 (3) and A2 (4), bearing bicyclo[3,2,0]heptadienones derived from tropolone, were photochemically produced and structurally identified by spectroscopic methods. Predicted by the machine learning-based assay, 1 significantly inhibited the action of tyrosinase. The new compounds also inhibited lipid accumulation and enhanced the extracellular glycerol excretion. English AMER CHEMICAL SOC PAPER CHROMATOGRAPHY PHOTOELECTROCYCLIZATION PHOTOCYCLIZATION CONFINEMENT HINOKITIOL INHIBITORS INDUCTION Tropolone-Bearing Sesquiterpenes from Juniperus chinensis: Structures, Photochemistry and Bioactivity Article 10.1021/acs.jnatprod.1c00321 1 JOURNAL OF NATURAL PRODUCTS, v.84, no.7, pp.2020 - 2027 JOURNAL OF NATURAL PRODUCTS 84 7 2020 2027 scie scopus 000677582700017 2-s2.0-85110978409 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article PAPER CHROMATOGRAPHY PHOTOELECTROCYCLIZATION PHOTOCYCLIZATION CONFINEMENT HINOKITIOL INHIBITORS INDUCTION Tropolone Sesquiterpene Juniperus chinensis Photochemistry