Kim, Hong-Rae Bong, Ji-Hong Park, Jun-Hee Song, Zhiquan Kang, Min-Jung Son, Dong Hee Pyun, Jae-Chul 2024-01-19T14:31:10Z 2024-01-19T14:31:10Z 2021-10-21 2021-06-30 1944-8244 https://pubs.kist.re.kr/handle/201004/116837 Chemiluminescence immunoassays have been widely employed for diagnosing various diseases. However, because of the extremely low intensity chemiluminescence signals, highly sensitive transducers, such as photomultiplier tubes and image sensors with cooling devices, are required to overcome this drawback. In this study, a hypersensitive photosensor was developed based on cesium lead bromide (CsPbBr3) perovskite quantum dots (QDs) with sufficient high sensitivity for chemiluminescence immunoassays. First, CsPbBr3 QDs with a highly uniform size, that is, 5 nm, were synthesized under thermodynamic control to achieve a high size confinement effect. For the fabrication of the photosensor, MoS2 nanoflakes were used as an electron transfer layer and heat-treated at an optimum temperature. Additionally, a parylene-C film was used as a passivation layer to improve the physical stability and sensitivity of the photosensor. In particular, the trap states on the CsPbBr3 QDs were reduced by the passivation layer, and the sensitivity was increased. Finally, a photosensor based on CsPbBr3 QDs was employed in chemiluminescence immunoassays for the detection of human hepatitis B surface antigen, human immunodeficiency virus antibody, and alpha-fetoprotein (AFP, a cancer biomarker). When compared with the conventionally used equipment, the photosensor was determined to be feasible for application in chemiluminescence immunoassays. English American Chemical Society ANION-EXCHANGE BR CL NANOCRYSTALS LUMINESCENT PERFORMANCE CSPBX3 Cesium Lead Bromide (CsPbBr3) Perovskite Quantum Dot-Based Photosensor for Chemiluminescence Immunoassays Article 10.1021/acsami.1c08128 1 ACS Applied Materials & Interfaces, v.13, no.25, pp.29392 - 29405 ACS Applied Materials & Interfaces 13 25 29392 29405 scie scopus 000670430100014 2-s2.0-85110091983 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article ANION-EXCHANGE BR CL NANOCRYSTALS LUMINESCENT PERFORMANCE CSPBX3 CsPbBr3 quantum dot photosensor passivation parylene MoS2 chemiluminescence immunoassay