Elbatrawy, Ahmed A. Lee, Da Sol Lee, Sang Bong Jeon, Hui-Jeon Lee, Sijoon Kang, Kyung-ku Sung, Soo-Eun Han, Ye Ri Cho, Sung Jin Kim, Dong-Su Kim, Kil Soo Nam, Ghilsoo Jeon, Yong Hyun 2024-01-19T14:31:11Z 2024-01-19T14:31:11Z 2021-10-21 2021-06-28 2050-7518 https://pubs.kist.re.kr/handle/201004/116839 Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects. In vivo fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without in vivo toxicity, which was consistent with the findings of ex vivo imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications. English ROYAL SOC CHEMISTRY INDOCYANINE GREEN FLUORESCENCE QUANTUM DOTS BIOPSY TRIAL FOCUS Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping Article 10.1039/d1tb00568e 1 JOURNAL OF MATERIALS CHEMISTRY B, v.9, no.24, pp.4857 - 4862 JOURNAL OF MATERIALS CHEMISTRY B 9 24 4857 4862 scie scopus 000656888700001 2-s2.0-85108677261 Materials Science, Biomaterials Materials Science Article INDOCYANINE GREEN FLUORESCENCE QUANTUM DOTS BIOPSY TRIAL FOCUS