Jeong, Ui-Jin Lee, Jungpyo Chou, Namsun Kim, Kanghwan Shin, Hyogeun Chae, Uikyu Yu, Hyun-Yong Cho, Il-Joo 2024-01-19T14:31:21Z 2024-01-19T14:31:21Z 2021-10-21 2021-06-21 1473-0197 https://pubs.kist.re.kr/handle/201004/116850 The minimal invasiveness of electrocorticography (ECoG) enabled its widespread use in clinical areas as well as in neuroscience research. However, most existing ECoG arrays require that the entire surface area of the brain that is to be recorded be exposed through a large craniotomy. We propose a device that overcomes this limitation, i.e., a minimally invasive, polyimide-based flexible array of electrodes that can enable the recording of ECoG signals in multiple regions of the brain with minimal exposure of the surface of the brain. Magnetic force-assisted positioning of a flexible electrode array enables recording from distant brain regions with a small cranial window. Also, a biodegradable organic compound used for attaching a magnet on the electrodes allows simple retrieval of the magnet. We demonstrate with an in vivo chronic recording that an implanted ECoG electrode array can record ECoG signals from the visual cortex and the motor cortex during a rat's free behavior. Our results indicate that the proposed device induced minimal damage to the animal. We expect the proposed device to be utilized for experiments for large-scale brain circuit analyses as well as clinical applications for intra-operative monitoring of epileptic activity. English Royal Society of Chemistry OSCILLATIONS CORTEX CONNECTIVITY TRANSPARENT FREQUENCY RIPPLES SURFACE UTILITY RAT A minimally invasive flexible electrode array for simultaneous recording of ECoG signals from multiple brain regions Article 10.1039/d1lc00117e 1 Lab on a Chip, v.21, no.12, pp.2383 - 2397 Lab on a Chip 21 12 2383 2397 scie scopus 000647585400001 2-s2.0-85108019553 Biochemical Research Methods Chemistry, Multidisciplinary Chemistry, Analytical Nanoscience & Nanotechnology Instruments & Instrumentation Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Instruments & Instrumentation Article OSCILLATIONS CORTEX CONNECTIVITY TRANSPARENT FREQUENCY RIPPLES SURFACE UTILITY RAT