Shim, Seung-Hwan Park, Hyejun Mishra, Neeraj Kumar Kim, In Su Lee, Jae Kyun Lee, Kiho Jalani, Hitesh B. Choi, Yongseok 2024-01-19T14:31:25Z 2024-01-19T14:31:25Z 2022-01-10 2021-06-15 2365-6549 https://pubs.kist.re.kr/handle/201004/116854 Herein, we report a simple and straightforward catalyst-free one-pot multi-component synthesis of quinazolin-4-carboxamides using 2-(2-aminophenyl)-N,N-dialkyl-2-oxoacetamide, aldehydes and ammonium acetate. As compared to the conventional approached for quinazolin-4-carboxamides synthesis, this transformation demonstrates very good reactivity by tolerating a large number of functional groups, and proceeds with good to moderate yields under mild conditions. Notably, the synthesized 6-bromoquinazolin-4-carboxamide was subjected to Suzuki-Miyaura cross-coupling and Buchwald-Hartwig C-N bond forming reactions providing a straightforward method to obtain structurally diverse and valuable quinazoline scaffolds. Furthermore, the reaction could be easily scaled up to gram scale. English WILEY-V C H VERLAG GMBH QUINAZOLINE DISCOVERY Catalyst-Free One-Pot Multi-Component Synthesis of 2-Substituted Quinazolin-4-carboxamides from 2-Aminophenyl-2-oxoacetamides, Aldehydes, and Ammonium Acetate Article 10.1002/slct.202100534 1 CHEMISTRYSELECT, v.6, no.22, pp.5446 - 5450 CHEMISTRYSELECT 6 22 5446 5450 scie scopus 000663296300011 2-s2.0-85108121457 Chemistry, Multidisciplinary Chemistry Article QUINAZOLINE DISCOVERY Carboxamide Catalyst-Free N-Heterocycles Multicomponent Reaction One-Pot Synthesis Quinazoline