Ryu, Byeol Cho, Hyo Moon Zhang, Mi Lee, Ba Wool Doan, Thi Phuong Park, Eun Jin Lee, Hee Ju Oh, Won Keun 2024-01-19T14:32:03Z 2024-01-19T14:32:03Z 2022-01-10 2021-06 0031-9422 https://pubs.kist.re.kr/handle/201004/116893 MS/MS-based molecular networking showed differences in the chemical profiles, especially the terpenoid-coupled-phloroglucinol clusters, of Psidium guajava grown in Jeju Island of South Korea ("Jejuguava"), Vietnam and China. A chemical investigation of the 95% EtOH extract of Jejuguava leaves revealed meroterpenoids characterized by a dihydropyran ring junction between an acylphloroglucinol structure and terpenoid, and named jejuguajavones A-J (1-10). Compounds (+/-)-8-(+/-)-10 are racemic mixtures that were separated using a chiral HPLC column. The chemical structures of all the isolated compounds (1-10) were determined by analyzing the spectroscopic data and performing electronic circular dichroism calculations. Among the isolates, compounds 1-4 exhibit inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) enzyme, and this result was confirmed by molecular docking simulations. English PERGAMON-ELSEVIER SCIENCE LTD A-C GLUCOSE INHIBITORS TEA Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking Article 10.1016/j.phytochem.2021.112723 1 PHYTOCHEMISTRY, v.186 PHYTOCHEMISTRY 186 scie scopus 000644703200007 2-s2.0-85103334471 Biochemistry & Molecular Biology Plant Sciences Biochemistry & Molecular Biology Plant Sciences Article A-C GLUCOSE INHIBITORS TEA Psidium guajava Myrtaceae Jejuguava MS/MS-based molecular networking Meroterpenoid PTP1B