Hwang, Hee Sook Kim, Hyosuk Han, Geonhee Lee, Jong Won Kim, Kwangmeyung Kwon, Ick Chan Yang, Yoosoo Kim, Sun Hwa 2024-01-19T14:32:16Z 2024-01-19T14:32:16Z 2022-01-10 2021-06 1661-6596 https://pubs.kist.re.kr/handle/201004/116906 Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques. English MDPI MESENCHYMAL STEM-CELLS DENDRITIC CELLS IMMUNE-RESPONSES LUNG INJURY EXOSOMES MICROPARTICLES DELIVERY NEUROINFLAMMATION MICROVESICLES RELEASE Extracellular Vesicles as Potential Therapeutics for Inflammatory Diseases Article 10.3390/ijms22115487 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.11 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 11 scie scopus 000660163400001 2-s2.0-85106047733 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review MESENCHYMAL STEM-CELLS DENDRITIC CELLS IMMUNE-RESPONSES LUNG INJURY EXOSOMES MICROPARTICLES DELIVERY NEUROINFLAMMATION MICROVESICLES RELEASE extracellular vesicle inflammatory disease EV engineering biomarker