Lee, Seunghyun Jeon, Hoyoon Shim, Shinyong Im, Maesoon Kim, Jinsik Kim, Jung Hoon Lee, Byung Chul 2024-01-19T14:32:25Z 2024-01-19T14:32:25Z 2021-10-21 2021-06 2045-2322 https://pubs.kist.re.kr/handle/201004/116916 Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. However, unfocused ultrasound with MBs (UUS-MBs) and an interchangeable acoustic lens can tune and enhance the pressure field for MB destruction to overcome the disadvantages of FUS-MB DDSs. We designed a lens suitable for an ultrasound-phased array probe and studied the optimal treatment conditions for MB destruction in vitro through an optical imaging setup. The DDS effects were evaluated in a rat hepatoma model using doxorubicin (DOX) treatment. A concave lens with a radius of curvature of 2.6 mm and a thickness of 4 mm was selected and fabricated. UUS-MBs with the acoustic lens at 60 V-pp for 32 cycles and a PRF of 1 kHz could induce MB destruction, promoting the DDS even under fluidic conditions. In the animal experiment, the UUS-MBs in the acoustic lens treatment group had a higher concentration of DOX in the tumor than the control group. Our system suggests uses an acoustic lens to increase DDS effectiveness by providing sufficient ultrasound irradiation to the MBs. English Nature Publishing Group Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens Article 10.1038/s41598-021-92097-z 1 Scientific Reports, v.11, no.1 Scientific Reports 11 1 Y scie scopus 000665142100022 2-s2.0-85108142469 Multidisciplinary Sciences Science & Technology - Other Topics Article BLOOD-BRAIN-BARRIER FOCUSED ULTRASOUND LIPOSOMAL DOXORUBICIN SONODYNAMIC THERAPY CONTRAST AGENTS Cancer Therapy Microbubble-mediated drug delivery Ultrasound Interchangeable acoustic lens