Bang, Seokyoung Lee, Songhyun Choi, Nakwon Kim, Hong Nam 2024-01-19T14:32:49Z 2024-01-19T14:32:49Z 2021-09-05 2021-06 2192-2640 https://pubs.kist.re.kr/handle/201004/116938 Neurodegenerative diseases are a group of disorders characterized by progressive degeneration of the structural and functional integrity of the central and peripheral nervous systems. Millions of people suffer from degenerative brain diseases worldwide, and the mortality continues to increase every year, causing a growing demand for knowledge of the underlying mechanisms and development of therapeutic targets. Conventional 2D-based cell culture platforms and animal models cannot fully recapitulate the pathophysiology, and this has limited the capability for estimating drug efficacy. Recently, engineered platforms, including brain organoids and brain-on-a-chip, have emerged. They mimic the physiology of brain tissue and reflect the fundamental pathophysiological signatures of neurodegenerative diseases, such as the accumulation of neurotoxic proteins, structural abnormalities, and functional loss. In this paper, recent advances in brain-mimetic platforms and their potential for modeling features of neurodegenerative diseases in vitro are reviewed. The development of a physiologically relevant model should help overcome unresolved neurodegenerative diseases. English John Wiley and Sons Ltd Emerging Brain-Pathophysiology-Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains-on-a-Chip Article 10.1002/adhm.202002119 1 Advanced healthcare materials, v.10, no.12 Advanced healthcare materials 10 12 N scie scopus 000653171500001 2-s2.0-85106253881 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Review; Early Access PLURIPOTENT STEM-CELLS IN-VITRO MODEL AMYOTROPHIC-LATERAL-SCLEROSIS OLIGOMERIC ALPHA-SYNUCLEIN AMYLOID-BETA OLIGOMERS ALZHEIMERS-DISEASE HUNTINGTONS-DISEASE NEURONAL NETWORKS 3D CULTURE 3-DIMENSIONAL CULTURE biomimetic matericals brains&#8208 on&#8208 a&#8208 chip brain organoids brain spheroids neurodegenerative diseases pathophysiology