Chung, Justin J.
Yoo, Jin
Sum, Brian S. T.
Li, Siwei
Lee, Soojin
Kim, Tae Hee
Li, Zhenlun
Stevens, Molly M.
Georgiou, Theoni K.
Jung, Youngmee
Jones, Julian R.
2024-01-19T14:32:57Z
2024-01-19T14:32:57Z
2021-09-04
2021-06
2192-2640
https://pubs.kist.re.kr/handle/201004/116946
Inorganic-organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica(,) which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate)-star-SiO2 hybrid inks are printed with pore channels in the range of 100-200 mu m. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre-osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic-organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials.
English
Wiley-Blackwell
3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution
Article
10.1002/adhm.202100117
1
Advanced Healthcare Materials, v.10, no.12
Advanced Healthcare Materials
10
12
N
scie
scopus
000647193600001
2-s2.0-85105326225
Engineering, Biomedical
Nanoscience & Nanotechnology
Materials Science, Biomaterials
Engineering
Science & Technology - Other Topics
Materials Science
Article
3D printing
biomaterials
bone substitutes
hybrids
sol‐
gels