Yang, Suah Sun, In-Cheol Hwang, Hee Sook Shim, Man Kyu Yoon, Hong Yeol Kim, Kwangmeyung 2024-01-19T14:33:32Z 2024-01-19T14:33:32Z 2021-09-05 2021-05-21 2050-7518 https://pubs.kist.re.kr/handle/201004/116981 Immunogenic cell death (ICD) occurring by chemical and physical stimuli has shown the potential to activate an adaptive immune response in the immune-competent living body through the release of danger-associated molecular patterns (DAMPs) into the tumor microenvironment (TME). However, limitations to the long-term immune responses and systemic toxicity of conventional ICD inducers have led to unsatisfactory therapeutic efficacy in ICD-based cancer immunotherapy. Until now, various nanoparticle-based ICD-inducers have been developed to induce an antitumor immune response without severe toxicity, and to efficiently elicit an anticancer immune response against target cancer cells. In this review, we introduce a recent advance in the designs and applications of nanoparticle-based therapeutics to elicit ICD for effective cancer immunotherapy. In particular, combination strategies of nanoparticle-based ICD inducers with typical theranostic modalities are introduced intensively. Subsequently, we discuss the expected challenges and future direction of nanoparticle-based ICD inducers to provide strategies for boosting ICD in cancer immunotherapy. These versatile designs and applications of nanoparticle-based therapeutics for ICD can provide advantages to improve the therapeutic efficacy of cancer immunotherapy. English ROYAL SOC CHEMISTRY Rediscovery of nanoparticle-based therapeutics: boosting immunogenic cell death for potential application in cancer immunotherapy Article 10.1039/d1tb00397f 1 JOURNAL OF MATERIALS CHEMISTRY B, v.9, no.19, pp.3983 - 4001 JOURNAL OF MATERIALS CHEMISTRY B 9 19 3983 4001 scie scopus 000644975000001 2-s2.0-85106620109 Materials Science, Biomaterials Materials Science Review